HIV - PRIMO-INFECTION The diagnosctic incredibly early principal symptomatic infections is of
Hiv and aids main interest in allowing a quick reaction by treatment solution using a important effect on the improvement of infection.
Additionally, an asymptomatic affected individual can arrive pay a visit to on a "risk taking", often sexual, but in addition a shared syringe, an harm to treatment, etc. .... The problem of "ART following publicity." poser.Il will no for a longer time reserved for skilled contamination and requires referral to an emergency division or hospital medical professional referral. Its achievements will rely on how early the commence (as soon as possible, ideally inside of 12 several hours, at worst inside 48 hrs) and the strict observance
In apply, risk review may be complicated and - a minimum of - a telephone make contact with with all the referent a wise perspective
Whatsoever the decision, management must integrate the therapeutic features, social and psychological.
SEMIOLOGY
Medical signs typically get started across the 15th day immediately after infection. but will not be extremely precise.
$ $ Flu-like or suggestive of MNI
---- Fever, headache, asthenia
---- Probably: rash (rash), ulceration in the oral mucosa or genital
---- Several several adenopathies showing while in the second week of enhancement.
Diarrhea and oral candidiasis ---- much less frequent but evocative
---- The neurological types early, uncommon, occasionally severe
The disease progresses around several weeks
BIOLOGY
* The p24 antigenicity may be the gold typical of prognosis of major infection.
It is actually current in 90% of circumstances J14 and precedes the appearance of antibodies from 8 to thirty days
the agP24 disappears just after 10 days if the antibodies appear
Its positivity prospects to hospitalization in a very specialized center.
* Attach an antibody anti-HIV by ELISA. Its positivity is achievable J22-26 immediately after infection. It need to be confirmed by a Western blot. It is practiced for reference reasons only. His negativity on this early stage is not intelligence.
* Take note: the search for HIV RNA will not be indicated while in the diagnostic stage. It will be carried out inside pre-therapeutic and monitoring with the affected person
Beneficial BIOLOGY
Hospitalization inside a specialized quick.
BIOLOGY Unfavorable
The negativity on the two checks (AC agP24 and anti HIV) doesn't remove 100% contamination
Vigilance, prevention recommendations and psychological assistance has to be preserved.
Only for anti-HIV by ELISA 3 months following the coverage will not likely say a prognosis of contamination.
Query: The hunt for HIV RNA lets it to shorten the waiting time period? Only the potential for phony positives appears to have been documented.
If chance evaluation crucial conclusion a "antiviral treatment method right after exposure" needs to be taken and so involves the intervention of a hospital physician referral.